Patents
2022
Title: -
Order Number: BR 10 2022 014372 2
Language: Portuguese
Deposit Country: Brazil
Deposit Date: 20 July 2022
Publication Date: –
Grant Date: –
Depositor's Name: Federal University of São Carlos (UFSCar) / ADB Research and Development LTDA.
Inventor's Name: -
Abstract: -
2021
Title: "3D-printed electrochemical biosensor for COVID-19 virus detection"
Order Number: BR 10 2021 018602 0
Language: Portuguese
Deposit Country: Brazil
Deposit Date: 17 Sep 2021
Publication Date: –
Grant Date: –
Depositor's Name: Federal University of São Carlos (UFSCar) / Federal University of Paraná (UFPR) / Federal University of Uberlândia (UFU)
Inventor's Name: Jéssica S. Stefano; Luiz R. G. Silva; Bruno C. Janegitz; Laís C. Brazaca; Luiz O. Orzari; Rodrigo A. A. Muñoz; Emanuel Carrilho; Luiz H. Marcolino-Junior; Márcio F. Bergamini
Abstract: The present invention relates to the development of an electrochemical biosensor for the detection and monitoring of the virus that causes COVID-19, SARS-CoV-2. The biosensor includes at least one conductive species in the filament. used to manufacture the base electrochemical sensor (later modified into a biosensor), this conductive species being composed of graphene, a metallic species modifying the surface of the base sensor, in this case being metallic gold, and by finally, a biological species to interact with the genetic material of the COVID-19 virus, in this case, the capture DNA sequence for biosensor production. The produced biosensors have a relatively low cost, allowing quick analysis, simple assembly, and they are produced from 3D printing.
Title: "Composites, conductive filaments for 3D printing, application of filaments in electroanalysis, and production process"
Order Number: BR 10 2021 015522 1
Language: Portuguese
Deposit Country: Brazil
Deposit Date: 06 Aug 2021
Publication Date: –
Grant Date: –
Depositor's Name: Federal University of São Carlos (UFSCar) / Federal University of Uberlândia (UFU)
Inventor's Name: Jéssica S. Stefano; Luiz R. G. Silva; Bruno C. Janegitz; Raquel G. Rocha; Eduardo M. Richter; Rodrigo A. A. Muñoz
Abstract: The present invention refers to the production of a new composite material used for the production of an electrically conductive filament, including at least one conductive species, this conductive species being graphite, in addition to a method for its production with the aid of extrusion technology. The filaments produced are applied to the production of 3D-printed sensors and biosensors, capable of detecting and monitoring chemical species of interest (metals, drugs, medicines, pesticides, compounds of interest, viruses, etc.) in medicinal, biological, environmental, and food samples. These sensors can be modified with specific biological material (antibodies) that will give rise to an electrochemical biosensor capable of detecting the virus that causes COVID-19 (SARS-CoV-2).
2020
Title: "Lab-made 3D-printed contact angle measurement adjustable holder"
Order Number: BR 10 2020 022611 8
Language: Portuguese
Deposit Country: Brazil
Deposit Date: 06 Nov 2020
Publication Date: 24 May 2022
Grant Date: –
Depositor's Name: University of Campinas (UNICAMP) / Federal University of São Carlos (UFSCar)
Inventor's Name: Vinicius A. O. P. Silva; Vinícius A. P. Tartare; Cristiane Kalinke; Paulo R. Oliveira; Daniel C. Souza; Juliano A. Bonacin; Bruno C. Janegitz
Abstract: The present invention refers to a device for measuring the contact angle on different substrates and solid electrodes for the characterization of surfaces in terms of hydrophobicity and hydrophilicity. The present invention is also included in the field of chemistry, physics, materials, engineering, and related fields.
Title: "Conductive ink using nail polish, its application in electroanalysis and its production process"
Order Number: BR 10 2020 014186 4
Language: Portuguese
Deposit Country: Brazil
Deposit Date: 10 Jul 2020
Publication Date: 25 Jan 2022
Grant Date: –
Depositor's Name: Federal University of São Carlos (UFSCar)
Inventor's Name: Bruno C. Janegitz; Isabela A. A. Andreotti; Jéssica R. Camargo; Luiz O. Orzari; Luiz H. Marcolino-Junior; Márcio F. Bergamini; André L. Santos; Regina M. Takeuchi; Lauro A. Pradela-Filho; Diele A. G. Araújo; Alexandre Gatti
Abstract: The present invention refers to a new composition of electrically conductive ink, including at least one conductive species, such conductive species being composed of powdered graphene and nail polish, in addition to a process for its production through mixing technology by asymmetric dual centrifugation. Such ink will be applied to chemically inert materials to compose electrochemical sensors, capable of detecting chemical species in medicinal, environmental, and food samples. The use of nail polish in the manufacture of conductive ink for electrodes and the method used are differentials, as this proves to be interesting in the development and printing of electrochemical sensors, significantly expanding the field of relatively low-cost sensors.
Title: "Flexible platinum electrodes used as electrochemical biosensors for determination of Parkinson's disease-related biomarkers and manufacturing method"
Order Number: BR 10 2020 010979 0
Language: Portuguese
Deposit Country: Brazil
Deposit Date: 29 May 2020
Publication Date: 22 Mar 2022
Grant Date: –
Depositor's Name: Federal University of São Carlos (UFSCar)
Inventor's Name: Gabriela C. M. Oliveira; Jefferson H. S. Carvalho; Nirton C. S. Vieira; Laís C. Brazaca; Bruno C. Janegitz
Abstract: The present invention refers to the development of sensors and immunosensors based on flexible platinum electrodes for the determination of biomarkers related to Parkinson's Disease. For the detection of the neurotransmitter dopamine, voltammetric techniques were applied, and square wave voltammetry (SWV) showed the best performance among the tested methods. For the detection of the DJ-1 deglycase protein (PARK7/DJ-1), in turn, specific antibodies against the protein were immobilized on the electrode surface and the electrochemical impedance spectroscopy (EIS) technique was used. The devices developed were able to determine the analytes in a simple, fast, and accurate way, even in complex samples (serum and synthetic urine). In addition, its working range includes the concentrations usually found in human samples, ensuring its application potential to aid in the diagnosis of the disease in a simple, fast, and low-cost way.
2019
Title: "Adhesive electrode devices for electrochemical applications and method of obtaining"
Order Number: BR 10 2019 009057 0
Language: Portuguese
Deposit Country: Brazil
Deposit Date: 03 May 2019
Publication Date: 03 Nov 2020
Grant Date: –
Depositor's Name: Federal University of São Carlos (UFSCar) / Federal University of Parana (UFPR)
Inventor's Name: Bruno C. Janegitz; Jéssica R. Camargo; Isabela A. A. Andreotti; Luiz O. Orzari; Márcio F. Bergamini; Luiz H. Marcolino-Junior; Alexandre Gatti
Abstract: The present invention refers to new adhesive devices for electrochemical applications and their method of obtaining, which are adhesive and disposable sensory devices for use in electroanalytical applications, obtained from a conductive ink, based on commercial automotive varnish and powdered graphite, which are deposited on a sheet of adhesive paper with a layer of conductive ink for subsequent formation of a thin film on its surface, stable and solid, which constitute the adhesive electrodes, which enable the construction of new architectures of electrochemical sensors, since the electrodes can be glued onto any chemically inert surface, such as paper, cardboard, PET, PVC, and others, enabling the scientific community to use countless bases for the development of its research with sensors and/biosensors.
2018
Title: "Process for obtaining tapioca film for modification of glassy carbon electrode and obtained products"
Order Number: BR 10 2018 001823 0
Language: Portuguese
Deposit Country: Brazil
Deposit Date: 29 Jan 2018
Publication Date: 13 Aug 2019
Grant Date: –
Depositor's Name: Federal University of São Carlos (UFSCar)
Inventor's Name: Bruno C. Janegitz; Gabriela C. M. Oliveira; Kelly R. Francisco; Luiz O. Orzari
Abstract: The present invention refers to the process of obtaining an organic film based on a dispersion of tapioca and 5% acetic acid solution, for use in modified electrodes as sensors and biosensors. The film obtained from a simple execution process, which involves stirring steps and temperature measurement to control and maintain ideal temperatures, is characterized as a thin, stable, and solid film, which aims to modify electrodes with nanomaterials such as TiO2 nanotubes and reduced graphene oxide, making their fixation stable and homogeneous. The adherent film obtained does not interfere with the nanomaterial, therefore, it has inert characteristics for this use, showing it can be used for modification of glassy carbon electrodes with potential for dispersion with TiO2 nanotubes and reduced graphene oxide, for presenting adequate dispersion and current passage, without charge interference between the film, the nanomaterial, and the analyte in question.
2017
Title: "Process for obtaining an electrochemical immunosensor. electrochemical immunosensor and its uses"
Order Number: BR 10 2017 019825 1
Language: Portuguese
Deposit Country: Brazil
Deposit Date: 15 Sep 2017
Publication Date: 16 Apr 2019
Grant Date: –
Depositor's Name: University of São Paulo (USP) / Federal University of São Carlos (UFSCar)
Inventor's Name: Valtencir Zucolotto; Bruno C. Janegitz; Camila B. Bramorski; Juliana C. Bernardi; Laís C. Brazaca; Regina P. Markus; Sanseray S. Cruz-Machado
Abstract: The present invention refers to a process for obtaining an electrochemical immunosensor based on the technique of cyclic voltammetry and/or electrochemical impedance spectroscopy, constructed through the coating of an ITO (Indium Tin Oxide) platform using the SAM (Self-Assembled Monolayers) technique, for the detection and quantification of melatonin hormone through APTES/EDC-NHS/Ab films. This immunosensor is capable of detecting melatonin in a concentration range from 0.75 to 7.5 μmol L–1 in a simple and fast way, presenting a calculated detection limit of 0.175 and 0.154 for EIS (Electrochemical Impedance Spectroscopy) and CV (Cyclic Voltammetry) techniques, respectively.
2016
Title: "Electrochemical DNA biosensor, the process for its preparation, and its use"
Order Number: BR 10 2016 022344 0
Language: Portuguese
Deposit Country: Brazil
Deposit Date: 27 Sep 2016
Publication Date: 02 May 2018
Grant Date: –
Depositor's Name: University of São Paulo (USP)
Inventor's Name: Juliana C. Bernardi; Valtencir Zucolotto; Bruno C. Janegitz; Camila B. Bramorski; Laís C. Brazaca
Abstract: The present invention relates to an electrochemical DNA biosensor based on the techniques of electrochemical impedance spectroscopy (EIS) and/or cyclic voltammetry (CV) for the simple, fast, and low-cost determination of genetic traits of sickle cell anemia, being capable to assist in genetic counseling. This biosensor is constructed from the three independent electrodes: a modified gold working electrode, a platinum plate counter electrode, and an Ag/AgCl reference electrode (3.0 mol L–1 KCl). Furthermore, the present invention relates to a process for the preparation of this electrochemical DNA biosensor, as well as its use.
Title: "Electrochemical DNA sensor, the process for its preparation, and its use"
Order Number: BR 10 2016 003449 3
Language: Portuguese
Deposit Country: Brazil
Deposit Date: 18 Feb 2016
Publication Date: 22 Aug 2017
Grant Date: –
Depositor's Name: University of São Paulo (USP)
Inventor's Name: Valtencir Zucolotto; Bruno C. Janegitz; Laís Ribovski
Abstract: The present invention describes an electrochemical DNA sensor based on the electrochemical techniques of cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) for the detection of c.68_69del mutation related to predisposition to breast and ovarian cancers located on chromosome 17. This sensor is constructed based on a three-electrode electrochemical system: an Ag/AgCl (3 mol L–1 KCl) reference electrode (RE), a platinum counter electrode (CE), and a working electrode (WE) with a gold bar. Additionally, the present invention relates to a process for the preparation of this sensor comprising three steps on the working electrode: capture DNA immobilization (HS-ssDNA), surface coating with 2-mercaptoethanol, and HS-ssDNA interaction with tarDNA or ncsDNA target.
2015
Title: "Process of obtaining a working electrode, electrochemical biosensor based on the cyclic voltammetry technique, its use and measurement method"
Order Number: BR 10 2015 025909 3
Language: Portuguese
Deposit Country: Brazil
Deposit Date: 09 Oct 2015
Publication Date: 16 May 2017
Grant Date: 10 May 2022
Depositor's Name: University of São Paulo (USP)
Inventor's Name: Valtencir Zucolotto; Regina P. Markus; Bruno C. Janegitz; Juliana C. Bernardi; Camila B. Bramorski; Laís C. Brazaca
Abstract: The present invention refers to a process for obtaining a working electrode responsible for the interaction with the melatonin hormone composed of a substrate platform covered with at least one PANI/PVS (polyaniline/polyvinyl sulfonic acid) thin film layer constructed through the LbL (layer-by-layer) technique. Additionally, the present invention refers to an electrochemical biosensor based on the cyclic voltammetry (CV) technique for the detection of the melatonin hormone, comprising 3 independent electrodes: reference, counter, and the working electrode, in which the latter is obtained according to the process described herein. Furthermore, the invention refers to the method of measuring the biosensor described herein and its use for the detection of the melatonin hormone, as well as for greater accuracy in the diagnosis of diseases related to melatonin, as well as for a better dosage of the drugs used in the treatment of these.
2014
Title: "Biosensors for detection and quantification of adiponectin hormone in a biological sample; method of production of biosensors for detection and quantification of adiponectin hormone; and method of diagnosing metabolic disorders"
Order Number: BR 10 2014 024605 3
Language: Portuguese
Deposit Country: Brazil
Deposit Date: 02 Oct 2014
Publication Date: 07 Feb 2017
Grant Date: 09 Nov 2021
Depositor's Name: University of São Paulo (USP)
Inventor's Name: Valtencir Zucolotto; Laís C. Brazaca; Bruno C. Janegitz; Juliana C. Bernardi
Abstract: This present invention refers to biosensors for the detection and quantification of adiponectin hormone in a biological sample that consist of an electrode coated with crosslinking agents; and, a detector biomolecule; the method of production of biosensors for detecting and quantifying the adiponectin hormone in a biological sample comprising the steps of electrode preparation; coating; and, immobilization of the detecting biomolecule; and, the metabolic diagnostic method by detecting and quantifying adiponectin in a biological sample.